Journal
ONCOTARGETS AND THERAPY
Volume 9, Issue -, Pages 2873-2884Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/OTT.S104691
Keywords
albumin; biological drug delivery systems; erythrocyte; platelet
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Funding
- National Natural Science Foundation of China [81400162, 81570174]
- Natural Science Foundation of Jiangsu Province [BK20140100]
- Technique Development Foundation of Nanjing (Outstanding Youth Foundation) [JQX15004]
- Innovation Program of Jiangsu Province [SJZZ15_0029]
- Medical Science and Technology Development Program of Nanjing [Ykk14069, 201402066]
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In the past few years, nanomaterial-based drug delivery systems have been applied to enhance the efficacy of therapeutics and to alleviate negative effects through the controlled delivery of targeting and releasing agents. However, few drug carriers can achieve high targeting efficacy, even when targeting modalities and surface markers are introduced. Immunological problems have also limited their wide applications. Biological drug delivery systems, such as erythrocytes, platelets, and albumin, have been extensively investigated because of their unique properties. In this review, erythrocytes, platelets, and albumin are described as efficient drug delivery systems. Their properties, applications, advantages, and limitations in disease treatment are explained. This review confirms that these systems can be used to facilitate a specific, biocompatible, and smart drug delivery.
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