Journal
MEDCHEMCOMM
Volume 7, Issue 8, Pages 1672-1680Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6md00277c
Keywords
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Funding
- National Natural Science Foundation of China [21372181, 21402144, 21572168, 21575157]
- Key Laboratory of Synthetic Chemistry of Natural Substances (Shanghai Institute of Organic Chemistry)
- State Key Laboratory for Modification of Chemical Fibers and Polymer Materials (Donghua University)
- NIH [RO1 CA69202, P30 CA023168]
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Fluorine is a highly attractive element for both medicinal chemistry and imaging technologies. To facilitate protein tyrosine phosphatase (PTP)-targeted drug discovery and imaging-guided PTP research on fluorine, several highly potent and F-19 MR sensitive PTP inhibitors were discovered through a structure-based focused library strategy.
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