Journal
MEDCHEMCOMM
Volume 7, Issue 9, Pages 1716-1729Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6md00287k
Keywords
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Funding
- US National Institutes of Health [R01M098453]
- University of Pisa
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM098453] Funding Source: NIH RePORTER
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The altered metabolism observed in cancer cells generally consists of increased glucose uptake and glycolytic activity. This is associated with an overexpression of glucose transporter proteins (GLUTs), which facilitate glucose uptake across the plasma membrane and play a crucial role in the survival of cancer cells. Therefore, GLUTs are considered as suitable targets for treatment of cancer. Herein we review some of the most relevant GLUT inhibitors that have been recently developed as prospective anticancer agents.
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