Journal
CHEMICAL SCIENCE
Volume 7, Issue 10, Pages 6407-6412Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6sc02653b
Keywords
-
Categories
Funding
- State Key Laboratory of Elemento-Organic Chemistry at Nankai University
- University of Pittsburgh
Ask authors/readers for more resources
A photoredox-mediated Minisci C-H alkylation reaction of N-heteroarenes with alkyl boronic acids is reported. A broad range of primary and secondary alkyl groups can be efficiently incorporated into various N-heteroarenes using [Ru(bpy)(3)]Cl-2 as photocatalyst and acetoxybenziodoxole as oxidant under mild conditions. The reaction exhibits excellent substrate scope and functional group tolerance, and offers a broadly applicable method for late-stage functionalization of complex substrates. Mechanistic experiments and computational studies suggest that an intramolecularly stabilized ortho-iodobenzoyloxy radical intermediate might play a key role in this reaction system.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available