Journal
CHEMICAL SCIENCE
Volume 7, Issue 4, Pages 2804-2808Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5sc04066c
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Funding
- NSF [CHE-1350541]
- Indiana University-Purdue University Indianapolis
- NSFC [21332005]
- Jiangsu Innovation Programs (P. R. China)
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1350541] Funding Source: National Science Foundation
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The direct cyanomethylation of unactivated sp(3) C-H bonds of aliphatic amides was achieved via palladium catalysis assisted by a bidentate directing group with good functional group compatibility. This process represents the first example of the direct cross-coupling of sp(3) C-H bonds with acetonitrile. Considering the importance of the cyano group in medicinal and synthetic organic chemistry, this reaction will find broad application in chemical research.
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