Journal
CHEMICAL SCIENCE
Volume 7, Issue 11, Pages 6695-6700Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6sc01320a
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [51502284, 21521092, 21590794, 51372242, 21210001]
- Hong Kong, Macao and Taiwan Science and Technology Cooperation Special Project of Ministry of Science and Technology of China [2014DFT10310]
- Program of Science and Technology Development Plan of Jilin Province of China [20140201007GX]
- National Key Basic Research Program of China [2014CB643802]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB20030300]
- Jilin Province Youth Foundation of China [20150520007JH]
Ask authors/readers for more resources
Mn-based nanoparticles have been regarded as a new class of probes for magnetic resonance imaging (MRI), but their low relaxivity is the major obstacle for applications in vivo. Herein, we designed and constructed a multifunctional nanotheranostic (FA-Mn3O4@PDA@PEG) for MRI guided combinatorial chemo-/photothermal therapy (PTT) for cancer. The ultrahigh relaxivity of 14.47 mM(-1) s(-1) makes the nanotheranostic an excellent contrast agent for MRI in vitro and in vivo, and provides comprehensive information for tumor diagnosis. When irradiated with an 808 nm NIR laser, FA-Mn3O4@PDA@PEG exhibits a remarkably improved and synergistic therapeutic effect compared to PTT or chemotherapy alone, providing high therapeutic efficiency and low side effects of drugs. These findings are of great interest and will inspire us to develop highly effective MRI guided synergetic chemo-/photothermal therapy for cancer treatment.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available