4.8 Article

Construction of spirocarbocycles via gold-catalyzed intramolecular dearomatization of naphthols

Journal

CHEMICAL SCIENCE
Volume 7, Issue 5, Pages 3427-3431

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5sc04130a

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Funding

  1. CAS/SAFEA International Partnership Program for Creative Research Teams
  2. National Basic Research Program of China (973 Program) [2015CB856600]
  3. NSFC [21332009, 21421091]

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A highly efficient, gold-catalyzed intramolecular dearomatization reaction of naphthols via 5-endo-dig cyclization is described. This facile and direct approach furnishes spirocarbocycles in excellent yields under mild conditions.

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