Journal
CHEMICAL SCIENCE
Volume 7, Issue 6, Pages 3737-3741Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5sc04133c
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Funding
- NSF China [21572189, 21272196, 91429301, 31420103910, 31330047, 31221065]
- Fundamental Research Funds for the Central Universities [20720160052, 20720150047]
- 973 program [2013CB933901]
- PCSIRT
- State Key Laboratory of Cellular Stress Biology, Xiamen University
- National Scientific and Technological Major Project [2013ZX10002-002]
- Hi-Tech Research and Development Program of China (863 program) [2012AA02A201]
- 111 Project [B12001]
- Science and Technology Foundation of Xiamen [3502Z20130027]
- National Science Foundation of China [J1310027]
- Open Research Fund of State Key Laboratory of Cellular Stress Biology, Xiamen University
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Techniques eliciting anti-tumor immunity are of interest for immunotherapy. We herein report the covalent incorporation of a non-self immunogen into the tumor glycocalyx by metabolic oligosaccharide engineering with 2,4-dinitrophenylated sialic acid ((DNP)Sia). This enables marked suppression of pulmonary metastasis and subcutaneous tumor growth of B16F10 melanoma cells in mice preimmunized to produce anti-DNP antibodies. Located on the exterior glycocalyx, (DNP)Sia is well-positioned to recruit antibodies. Given the high levels of natural anti-DNP antibodies in humans and ubiquitous sialylation across many cancers, (DNP)Sia offers a simplified route to redirect immunity against diverse tumors without recourse to preimmunization.
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