Journal
CHEMICAL SCIENCE
Volume 7, Issue 12, Pages 6940-6945Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6sc02466a
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Funding
- DAE-BRNS [2013/37C/56/BRNS/2440]
- Council of Scientific and Industrial Research (CSIR), New Delhi
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An enantioselective dearomatization of isoquinolines has been developed using chiral anion-binding catalysis. This transformation, catalyzed by a simple and easy to prepare tert-leucine-based thiourea derivative, makes use of silyl phosphite as a nucleophile and generates cyclic alpha-aminophosphonates. This is the first time asymmetric anion-binding catalysis has been applied to the synthesis of alpha-aminophosphonates.
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