Journal
CHEMICAL SCIENCE
Volume 7, Issue 5, Pages 3298-3303Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6sc00045b
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Funding
- Spanish grants [SAF2013-41943-R, CTQ2013-43264-R, CTQ2013-49317-EXP]
- Xunta de Galicia [GRC2013-041]
- ERDF
- European Research Council [340055]
- COST Action [CM1105]
- COST [CM1306]
- orfeo-cinqa network
- Xunta de Galicia
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We report the rational design of a DNA-binding peptide construct composed of the DNA-contacting regions of two transcription factors (GCN4 and GAGA) linked through an AT-hook DNA anchor. The resulting chimera, which represents a new, non-natural DNA binding motif, binds with high affinity and selectivity to a long composite sequence of 13 base pairs (TCAT-AATT-GAGAG).
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