Journal
ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE
Volume 9, Issue 3, Pages 269-272Publisher
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.1016/j.apjtm.2016.01.027
Keywords
Nuclear transcription factor-kappa B; Traumatic brain injury; Astrocytes; Rat
Funding
- Technology Program for Development of Pharmacy of Shandong [2013WS0351]
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Objective: To observe the effect of nuclear transcription factor-kappa B (NF-kappa B) on cerebral edema in rats with traumatic brain injury (TBI). Methods: Male SD rats with fluid percussion injury (FPI) were selected. After separation and culture, rats' astrocytes all suffered FPI. The expression of NF-kappa B and the water content were detected at the animal and cellular levels, while the activity of NOX was evaluated at the cellular level. Results: According to the results, the positive expression of NF-kappa B and expression of mRNA were significantly increased and the water content was increased for rats after TBI, while NF-kappa B inhibitor BAY11-7082 could significantly reduce the effect of TBI. 1 and 3h after FPI of astrocytes, the activation of NF-kappa B was increased and BAY 11-7082 could significantly improve the injury-induced swelling of astrocytes. After the injury of astrocytes, the activity of NOX was also increased, while BAY 11-7082 could reduce the activity of NOX. Conclusions: The results show that the activation of NF-kappa B in astrocytes is a key factor in the process of cerebral edema after TBI of rats.
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