Journal
JOURNAL OF TOXICOLOGIC PATHOLOGY
Volume 29, Issue 2, Pages 95-102Publisher
JAPANESE SOC TOXICOLOGIC PATHOLOGY
DOI: 10.1293/tox.2015-0067
Keywords
lung inflammation; mice; polyhexamethyleneguanidine phosphate; pulmonary fibrosis
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Funding
- Korea Environmental Industry and Technology Institute [2012001370006]
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Although several animal models have been developed to study human pulmonary fibrosis, lack of a perfect model has raised the need for various animal models of pulmonary fibrosis. In this study, we evaluated the pulmonary effect of polyhexamethyleneguanidine phosphate instillation into the lungs of mice to determine the potential of these mice as a murine model of pulmonary fibrosis. Intratracheal instillation of polyhexamethyleneguanidine phosphate induced severe lung inflammation manifested by the infiltration of mononuclear cells and neutrophils and increased production of IL-6, TNF-alpha, CCL2 and CXCL1. The lung inflammation gradually increased until 28 days after polyhexamethyleneguanidine phosphate exposure, and increases of collagen deposition and TGF-beta production, which are indicators of pulmonary fibrosis, were seen. Our study showed that intratracheal instillation of polyhexamethyleneguanidine phosphate induces pulmonary inflammation and fibrosis in mice.
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