Journal
VIRUSES-BASEL
Volume 8, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/v8120335
Keywords
picornavirus; Picornaviridae; poliovirus; coxsackievirus; human rhinovirus; RNA degradation; mRNA decay; RNA stability; RNase L; deadenylase
Categories
Funding
- U.S. Public Health Service from the National Institutes of Health [AI022693, AI026765, AI110782]
- U.S. Public Health Service training grant from the National Institutes of Health [AI007319]
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To successfully replicate, viruses protect their genomic material from degradation by the host cell. RNA viruses must contend with numerous destabilizing host cell processes including mRNA decay pathways and viral RNA (vRNA) degradation resulting from the antiviral response. Members of the Picornaviridae family of small RNA viruses have evolved numerous diverse strategies to evade RNA decay, including incorporation of stabilizing elements into vRNA and re-purposing host stability factors. Viral proteins are deployed to disrupt and inhibit components of the decay machinery and to redirect decay machinery to the advantage of the virus. This review summarizes documented interactions of picornaviruses with cellular RNA decay pathways and processes.
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