Journal
VIRUSES-BASEL
Volume 8, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/v8090242
Keywords
polyomavirus; SV40; ERAD; protein aggregation; membrane penetration
Categories
Funding
- National Institutes of Health [RO1 AI064296-10, RO1 GM113722]
Ask authors/readers for more resources
To infect cells, polyomavirus (PyV) traffics from the cell surface to the endoplasmic reticulum (ER) where it hijacks elements of the ER-associated degradation (ERAD) machinery to penetrate the ER membrane and reach the cytosol. From the cytosol, the virus transports to the nucleus, enabling transcription and replication of the viral genome that leads to lytic infection or cellular transformation. How PyV exploits the ERAD machinery to cross the ER membrane and access the cytosol, a decisive infection step, remains enigmatic. However, recent studies have slowly unraveled many aspects of this process. These emerging insights should advance our efforts to develop more effective therapies against PyV-induced human diseases.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available