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NEW ENGLAND JOURNAL OF MEDICINE (2011)
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Marc Y. Donath et al.
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Neil B. Ruderman et al.
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Mammalian Sirtuins: Biological Insights and Disease Relevance
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CD36 deficiency attenuates experimental mycobacterial infection
Michael Hawkes et al.
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Boglarka Racz et al.
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Hangxing Yu et al.
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Xueqing Ba et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Ellagic acid inhibits oxidized LDL-mediated LOX-1 expression, ROS generation, and inflammation in human endothelial cells
Wen-Jane Lee et al.
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Induction of ER Stress in Macrophages of Tuberculosis Granulomas
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PLOS ONE (2010)
The NAD World: A New Systemic Regulatory Network for Metabolism and Aging-Sirt1, Systemic NAD Biosynthesis, and Their Importance
Shin-ichiro Imai
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Vitamin D3 Induces Autophagy in Human Monocytes/Macrophages via Cathelicidin
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CELL HOST & MICROBE (2009)
Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation
Hye-Sook Kwon et al.
CELL HOST & MICROBE (2008)
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Coenraad Kuijl et al.
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Malka Cohen-Armon
TRENDS IN PHARMACOLOGICAL SCIENCES (2007)
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INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2007)
The Wingless homolog, WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation
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K Wennerberg et al.
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L Zheng et al.
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