Journal
CLINICAL INFECTIOUS DISEASES
Volume 60, Issue 6, Pages 919-923Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciu912
Keywords
VA/HMO astrovirus clade; encephalitis; deafness; next-generation sequencing; pathogen discovery
Categories
Funding
- National Institutes of Health [R01-HL105704]
- University of California Discovery Award
- Abbott Viral Discovery Award
- National Institute for Health Research Biomedical Research Centre
- National Institute for Health Research Experimental Cancer Medicine Centre
- MRC [MR/K000608/1] Funding Source: UKRI
- Medical Research Council [MR/K000608/1] Funding Source: researchfish
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Metagenomic next-generation sequencing (NGS) was used to diagnose an unusual and fatal case of progressive encephalitis in an immunocompromised adult presenting at disease onset as bilateral hearing loss. The sequencing and confirmatory studies revealed neuroinvasive infection of the brain by an astrovirus belonging to a recently discovered VA/HMO clade.
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