Journal
CLINICAL INFECTIOUS DISEASES
Volume 61, Issue 8, Pages 1304-1306Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/civ474
Keywords
HBV/HCV coinfection; HBV reactivation; acute hepatitis; sofosbuvir; simeprevir
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Treatment of hepatitis C virus with potent, interferon-free, direct-acting antiviral regimens with no activity against hepatitis B virus (HBV) may increase the risk for HBV reactivation in coinfected patients. We present 2 cases of HBV reactivation during treatment with an all-oral regimen of simeprevir and sofosbuvir and discuss strategies to prevent HBV flare.
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