Journal
CLINICAL INFECTIOUS DISEASES
Volume 61, Issue -, Pages S733-S737Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/civ849
Keywords
stunting; aflatoxin; fumonisin; deoxynivalenol; mycotoxin
Categories
Funding
- Bill & Melinda Gates Foundation [OPP1021542, OPP1066254]
- Department for International Development, UK
- Wellcome Trust, UK [093768/Z/10/Z]
- Swiss Agency for Development and Cooperation
- US National Institutes of Health (NIH) [2R01HD060338-06, 1R21 ES023980-01A1]
- European Union
- Bureau for Food Security, US Agency for International Development
- US Department of Agriculture, National Institute of Food and Agriculture Predoctoral Fellowship Program
- Atkinson Center for a Sustainable Future, Cornell University
- Bill and Melinda Gates Foundation [OPP1066254] Funding Source: Bill and Melinda Gates Foundation
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Children in developing countries experience multiple exposures that are harmful to their growth and development. An emerging concern is frequent exposure to mycotoxins that contaminate a wide range of staple foods, including maize and groundnuts. Three mycotoxins are suspected to contribute to poor child health and development: aflatoxin, fumonisin, and deoxynivalenol. We summarize the evidence that mycotoxin exposure is associated with stunting, and propose that the causal pathway may be through environmental enteric dysfunction (EED) and disturbance of the insulin-like growth factor 1 (IGF-1) axis. The objectives of this substudy are to assess the relationship between agricultural and harvest practices and mycotoxin exposure; to evaluate associations between mycotoxin exposure and child stunting; and to investigate EED as a potential pathway linking mycotoxin exposure to child stunting, to inform potential areas for intervention.
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