Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 22, Issue 7, Pages 2195-2205Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v22.i7.2195
Keywords
Inflammatory bowel disease; Regulatory T cell; Animal model; Therapy
Categories
Funding
- Ministry of Education, Science, Sport, and Culture of Japan [24659839, 24689068]
- Grants-in-Aid for Scientific Research [24689068, 24659839] Funding Source: KAKEN
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Regulatory T (T-reg) cells play key roles in various immune responses. For example, T-reg cells contribute to the complex pathogenesis of inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis during onset or development of that disease. Many animal models of IBD have been used to investigate factors such as pathogenic cytokines, pathogenic bacteria, and T-cell functions, including those of Treg cells. In addition, analyses of patients with IBD facilitate our understanding of the precise mechanism of IBD. This review article focuses on the role of Treg cells and outlines the pathogenesis and therapeutic strategies of IBD based on previous reports.
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