Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 22, Issue 11, Pages 3117-3126Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v22.i11.3117
Keywords
Claudin; Tight junction; Ulcerative colitis; Pouchitis; Crohn's disease
Categories
Funding
- Association for International Cancer Research (AICR), Scotland
- AICR [120234]
- BBSRC Strategic Research Grant [WMNIP33458]
- St Mark's Hospital Foundation, United Kingdom
- Worldwide Cancer Research [12-0234] Funding Source: researchfish
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Inflammatory bowel diseases are characterised by inflammation that compromises the integrity of the epithelial barrier. The intestinal epithelium is not only a static barrier but has evolved complex mechanisms to control and regulate bacterial interactions with the mucosal surface. Apical tight junction proteins are critical in the maintenance of epithelial barrier function and control of paracellular permeability. The characterisation of alterations in tight junction proteins as key players in epithelial barrier function in inflammatory bowel diseases is rapidly enhancing our understanding of critical mechanisms in disease pathogenesis as well as novel therapeutic opportunities. Here we give an overview of recent literature focusing on the role of tight junction proteins, in particular claudins, in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer.
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