Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 22, Issue 4, Pages 1477-1486Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v22.i4.1477
Keywords
Hepatitis C virus; Host restriction factor; Interferon; Entry; Replication; Propagation
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Funding
- National Natural Science Foundation of China [81271832, 81471955]
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Host-hepatitis C virus (HCV) interactions have both informed fundamental concepts of viral replication and pathogenesis and provided novel insights into host cell biology. These findings are illustrated by the recent discovery of host-encoded factors that restrict HCV infection. In this review, we briefly discuss these restriction factors in different steps of HCV infection. In each case, we discuss how these restriction factors were identified, the mechanisms by which they inhibit HCV infection and their potential contribution to viral pathogenesis.
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