Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 22, Issue 6, Pages 1953-1965Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v22.i6.1953
Keywords
Apolipoproteins; Hepatitis C virus; Lipid metabolism; Lipoproteins; Review
Categories
Funding
- AIRC [IG-13529]
- Ministry for Health of Italy
- Ministry of University and Research of Italy
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Hepatitis C virus (HCV) infects over 150 million people worldwide. In most cases, HCV infection becomes chronic causing liver disease ranging from fibrosis to cirrhosis and hepatocellular carcinoma. Viral persistence and pathogenesis are due to the ability of HCV to deregulate specific host processes, mainly lipid metabolism and innate immunity. In particular, HCV exploits the lipoprotein machineries for almost all steps of its life cycle. The aim of this review is to summarize current knowledge concerning the interplay between HCV and lipoprotein metabolism. We discuss the role played by members of lipoproteins in HCV entry, replication and virion production.
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