Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 22, Issue 11, Pages 3302-3304Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v22.i11.3302
Keywords
Acetaminophen hepatotoxicity; Liuweiwuling; Sterile inflammation; Natural products; Liver regeneration
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Funding
- National Institutes of Health [R01 DK102142, R01 AA12916]
- National Institute of General Medical Sciences of the National Institutes of Health [8 P20 GM103549-07]
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Study of the effects of natural products, including traditional Chinese Medicines, on acetaminophen hepatotoxicity has gained considerable popularity in recent years, and some of them showed positive results and even promising therapeutic potentials. A recent report suggested that Liuweiwuling tablets protect against acetaminophen hepatotoxicity and promote liver regeneration in a rodent model through alleviating the inflammatory response. However, several concerns exist regarding the limitations of the experimental design and interpretation of the data presented in this manuscript.
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