4.6 Review

Combined hepatocellular cholangiocarcinoma: Controversies to be addressed

Journal

WORLD JOURNAL OF GASTROENTEROLOGY
Volume 22, Issue 18, Pages 4459-4465

Publisher

BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v22.i18.4459

Keywords

Progenitor cell origin; Pathology classification; Combined hepatocellular cholangiocarcinoma

Ask authors/readers for more resources

Combined hepatocellular cholangiocarcinoma (CHC) accounts for 0.4%-14.2% of primary liver cancer cases and possesses pathological features of both hepatocellular carcinoma and cholangiocarcinoma. Since this disease was first described and classified in 1949, the classification of CHC has continuously evolved. The latest definition and classification of CHC by the World Health Organization is based on the speculation that CHC arises from hepatic progenitor cells. However, there is no evidence demonstrating the common origin of different components of CHC. Furthermore, the definition of CHC subtypes is still ambiguous and the identification of CHC subtype when a single tumor contains many components has remained unresolved. In addition, there is no summary on the newly recognized histopathology features or the contribution of CHC components to prognosis and outcome of this disease. Here we provide a review of the current literature to address these questions.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available