Journal
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
Volume 18, Issue 1, Pages 63-70Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/15622975.2016.1155746
Keywords
Biomarker; bipolar disorder; C-reactive protein; inflammation; major depressive disorder
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Funding
- National Science Council of Taiwan [NSC 93-2314-B-006-107, NSC 97-2314-B-006-006-MY3, NSC 98-2627-B-006-016, NSC 99-2627-B-006-014, NSC 100-2314-B-006-041-MY3, NSC 100-2627-B-006-012, NSC 101-2314-B-006-064-MY3, NSC 101-2314-B-006-065]
- Ministry of Science and Technology, Taiwan [MOST 103-2320-B-006 -013, MOST 104-2320-B-006 -024]
- Department of Health, Taiwan [DOH96-TD-D-113-041]
- National Cheng Kung University Hospital [NCKUH-10301003]
- Headquarters of University Advancement at the National Cheng Kung University [D102-35001, D103-35A09]
- Ministry of Education, Taiwan, ROC
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Objectives We aimed to examine whether the C-reactive protein (CRP) level could be used to differentiate between major depressive disorder (MDD) and bipolar II disorder (BD II). Methods Ninety-six healthy controls, 88 BD II and 72 MDD drug-naive patients in their major depressive episodes were enrolled. The fasting plasma level of high-sensitivity CRP was assessed at baseline and after treatment. Results The BD II patients presented significantly higher 17-item Hamilton Depression Rating Scale (HDRS) scores and CRP levels at baseline when adjustment for age, gender, and body mass index (P< 0.001 and P< 0.001, respectively). After treatment the CRP levels remained significantly different (P< 0.001), although the HDRS score was not significantly different between the BD II and MDD patients. A receiver-operating characteristic analysis showed that a baseline CRP level of 621.6ng/mL could discriminate between BD II and MDD, with an area under the curve of 0.816 and a sensitivity and specificity of 0.699 and 0.882, respectively. Furthermore, the baseline CRP level greater than 621.6ng/ml had 28.2 higher odds of a diagnosis of BD II (P< 0.001, 95% confidence interval: 10.96-72.35). Conclusions The level of CRP plays a role of biomarker to differentiate between MDD and BD II depression in both their depressed and euthymic state.
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