Journal
CLINICAL INFECTIOUS DISEASES
Volume 61, Issue -, Pages S48-S57Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/civ523
Keywords
antimicrobial resistance; multidrug-resistant; methicillin-resistant; vancomycin-resistant; penicillin-resistant
Categories
Funding
- Theravance Biopharma Antibiotics, Inc
- Chilean Ministry of Education
- Clinical Alemana de Santiago
- Universidad del Desarrollo School of Medicine, Chile
- National Institute of Allergy and Infectious Diseases, National Institutes of Health [R01 AI39108-15, R01 AI093749]
Ask authors/readers for more resources
Antimicrobial therapy is a key component of modern medical practice and a cornerstone for the development of complex clinical interventions in critically ill patients. Unfortunately, the increasing problem of antimicrobial resistance is now recognized as a major public health threat jeopardizing the care of thousands of patients worldwide. Gram-positive pathogens exhibit an immense genetic repertoire to adapt and develop resistance to virtually all antimicrobials clinically available. As more molecules become available to treat resistant gram-positive infections, resistance emerges as an evolutionary response. Thus, antimicrobial resistance has to be envisaged as an evolving phenomenon that demands constant surveillance and continuous efforts to identify emerging mechanisms of resistance to optimize the use of antibiotics and create strategies to circumvent this problem. Here, we will provide a broad perspective on the clinical aspects of antibiotic resistance in relevant gram-positive pathogens with emphasis on the mechanistic strategies used by these organisms to avoid being killed by commonly used antimicrobial agents.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available