Journal
CLINICAL IMMUNOLOGY
Volume 158, Issue 2, Pages 204-211Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2015.02.016
Keywords
Allergic rhinitis; Bronchial asthma; Tfh cells; Tfh2 cells; Regulatory B cells
Categories
Funding
- GSK Japan Research Grant
- Japan Society for the Promotion of Science (JSPS) [26893213, 26861398, 26861400, 26293370, 26670746, 26670178]
- Grants-in-Aid for Scientific Research [26293370, 26861400, 15K10787, 15K16399, 26893213, 26670746, 26861398, 26670178] Funding Source: KAKEN
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Allergic rhinitis (AR), the most common allergic disorder of the airway, is often accompanied by bronchial asthma. However, little is known about the mechanism by which AR advances to AR comorbid with bronchial asthma (AR + Asthma). To determine the pathophysiologic features of AR and AR + Asthma, we examined subsets of follicular helper T (Tfh) cells and regulatory B (Breg) cells in peripheral blood from AR and AR + Asthma patients. The results showed polarization of Tfh2 cells within Tfh cell subsets in both AR and AR + Asthma cases. Interestingly, the %Breg cells in total B cells were decreased in AR cases and, more extensively, in AR + Asthma cases. Moreover, we found significant correlations of fractional exhaled nitricoxide and blood eosinophil levels with the index %Tfh2 cells per %Breg cells. Our findings indicate that relative decrease in Breg cells under the condition of Tfh2 cell skewing is a putative exaggerating factor of AR to bronchial asthma. (C) 2015 The Authors. Published by Elsevier Inc.
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