Journal
CLINICAL IMMUNOLOGY
Volume 159, Issue 2, Pages 163-169Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2015.03.019
Keywords
Microbiome; Osteoblast; Osteoclast; Osteoimmunology
Categories
Funding
- NIH [K08 AR062590, R03 AR066357, R01 AR060363, R01 AG046257]
- Burroughs Wellcome Fund
- Rheumatology Research Foundation Career Development Bridge Funding Award
- Bettina Looram Fund
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Recent advances have dramatically increased our understanding of how organ systems interact. This has been especially true for immunology and bone biology, where the term osteoimmunology was coined to capture this relationship. The importance of the microbiome to the immune system has also emerged as a driver of health and disease. It makes sense therefore to ask the question: how does the intestinal microbiome influence bone biology and does dysbiosis promote bone disease? Surprisingly, few studies have analyzed this connection. A broader interpretation of this question reveals many mechanisms whereby the microbiome may affect bone cells. These include effects of the microbiome on immune cells, including myeloid progenitors and Th17 cells, as well as steroid hormones, fatty acids, serotonin and vitamin D. As mechanistic interactions of the microbiome and skeletal system are revealed within and without the immune system, novel strategies to optimize skeletal fitness may emerge. (C) 2015 Elsevier Inc. All rights reserved.
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