Journal
CLINICAL IMMUNOLOGY
Volume 157, Issue 2, Pages 175-186Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2015.02.001
Keywords
Myeloid-derived suppressor cells; Collagen-induced arthritis; Th17 cells; IL-1 beta
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Funding
- Guangzhou Science and Technology Planning Program [2012J4100085]
- National Natural Science Foundation of China [81273278, 81471598]
- PhD Program Foundation of Ministry of Education of China [20120171110064]
- Guangdong Natural Science Foundation [S2012010008780, S2011010004578]
- National Institutes of Health [R01-AR047988, R01-AR049449]
- Alliance for Lupus Research
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Myeloid-derived suppressor cells (MDSC) and Th17 cells were found to expand in collagen-induced arthritis (CIA) significantly. Two subsets of MDSC, polymorphonuclear (PMN) and mononuclear (MO), were detected and their ratios varied during the development of CIA. The depletion of MDSC in vivo resulted in suppression of T-cell proliferation and decreased IL-17A and IL-1 beta production. The adoptive transfer of MDSC restored the severity of arthritis and Th17 cell differentiation. The depletion of MDSCs on day 35 resulted in arthritis amelioration without reaching a significant difference. Furthermore, MDSCs from CIA mice had higher production of IL-1 beta and promoted Th17 cell differentiation. The expansion of MDSCs in the peripheral blood of rheumatoid arthritis (RA) patients was in correlation with increased Th17 cells and disease activity DAS28. These results support the hypothesis that MDSC may play a significant proinflammatory role in the pathogenesis of CIA and RA by inducing Th17 development in an IL-1 beta-dependent manner. (C) 2015 Elsevier Inc. All rights reserved.
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