Journal
CLINICAL IMMUNOLOGY
Volume 157, Issue 2, Pages 103-113Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2015.01.007
Keywords
EoE; ICAM; Interleukin-IL-18; IL-18R alpha; iNKT cells
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Funding
- NIH [RO1 DK067255, R01 AI080581]
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IL-18 is induced in food allergy and EoE is food allergen-induced disease. Therefore, we tested the hypothesis whether IL-18 is involved in food allergen-induced EoE pathogenesis. Accordingly, we examined normal SPT+ and SPT - EoE patient blood and biopsy samples for IL-18, IL-18R alpha, ICAM and VCAM expression. Herein, we show increased IL-18 level is highly significant in food allergen SPT+ compared to SPT EoE patients. We also report that IL-18R alpha+ cells and mRNA levels are induced in the esophageal biopsies of EoE patients and blood IL-18 levels correlate with esophageal eosinophilia (P < 0.01). Additionally, we report that the levels of esophageal eosinophil and mast cells correlate with ICAM expression in human EoE. Mechanistically, we show that IL-18 in vitro stimulates iNKT cells and endothelial cells and induce eosinophil active cytokines IL-5 and IL-13. We provide the evidence that IL-18 is critical cytokine involved in activation of iNKT cells and ICAM in promoting human EoE. (C) 2015 Elsevier Inc. All rights reserved.
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