Journal
WIENER KLINISCHE WOCHENSCHRIFT
Volume 128, Issue 15-16, Pages 586-591Publisher
SPRINGER WIEN
DOI: 10.1007/s00508-016-0977-x
Keywords
Cytomegalovirus; Essential hypertension; Meta-analysis
Categories
Funding
- Joint Funds of the National Natural Science Foundation of China [U1403123]
- Ministry of Major Science & Technology of Shihezi University [gxjs2013-zdgg04, gxjs2013-zdgg04-1, gxjs2013-zdgg04-2, gxjs2013-zdgg04-3, gxjs2013-zdgg04-4]
- Xinjiang Graduate Student Research Innovation Project [XJGRI2015054]
Ask authors/readers for more resources
Information regarding association between cytomegalovirus (CMV) infection and essential hypertension (EH) risk is not consistent across studies. Therefore, we conducted a meta-analysis to investigate the association in detail. We comprehensively searched the published literature from the PubMed and Embase databases for any study analyzing the association between CMV and EH risk. A random-effects model was used to calculate the pooled odds ratio (OR) with 95 % confidence interval (CI). Three studies involving 9657 patients were included in the meta-analysis, and the results showed a significantly increased risk of EH in patients with CMV infection. Overall, 79.3 % of the hypertension patients were CMV-positive, which was significantly higher than the percentage for controls (OR = 1.39, 95 % CI = 0.95-2.05, P = 0.017). There was significant heterogeneity among the studies included (I-2 = 70.5 %). The funnel plot and Egger's test also indicated no publication bias. The results showed a significant association between CMV and EH, which indicates that CMV infection is a possible cause of EH.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available