Journal
CLINICAL IMAGING
Volume 39, Issue 5, Pages 775-780Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.clinimag.2015.04.003
Keywords
Glioblastoma; Pseudoprogression; Magnetic resonance imaging; Texture analysis; Gray level co-occurrence matric
Funding
- Science and Technology Planning Project of Guangdong Province [2013B021800063]
- Science and Technology Planning Project of Guangzhou [2014J4100071]
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Twenty-two patients with pathologically confirmed glioblastoma who had received concurrent CCRT with TMZ underwent conventional MRI including T1-weighted imaging(T1WI),T2-weighted imaging(T2WI), fluid attenuated inversion recovely(FLAIR)and contrast-enhanced T1WI(T1Ce). Five GLCM texture maps of contrast, energy, entropy, correlation and homogeneity were generated for each MRI series. Of the aforementioned 5 texture features, the most significant features were contrast and correlation on T2WI with areas under ROC curve of 0.883 and 0.892, respectively, and they had the same sensitivity of 75%, specificity of 100%, accuracy of 86.4%, PPV of 100% and NPV of 76.9% in differentiation true progression from pseudoprogression. (C) 2015 Published by Elsevier Inc.
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