Optimal cut-off value of perfusion parameters for diagnosing prostate cancer and for assessing aggressiveness associated with Gleason score

To determine cut-off value of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) parameters for differentiation of prostate malignant from benign and cancer with high-grade Gleason score (GS) (GS>7) from low-grade GS (GS <= 7), 35 patients (24 malignant and 11 benign) who underwent DCE-MRI were included. Difference between malignant and benign was statistically significant for all magnetic resonance parameters except V-e. The cut-off values were K-trans=0.184 min(-1), K-ep= 0.695 min(-1), iAUC=4.219 mmol/l/min, and ADC= 1340.5 mm(2)/s. A significant difference in mean values of K-trans and K-ep between cancer with high-grade GS and low-grade GS was also observed. K-trans and K-ep showed a significant correlation with GS. (C) 2015 Elsevier Inc. All rights reserved.