Journal
VIRUS RESEARCH
Volume 212, Issue -, Pages 127-136Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.virusres.2015.09.023
Keywords
IFN; Interferon; IncRNA; Long non-coding RNA; NRIR; BISPR
Categories
Funding
- CFAR [P30-AI036219]
Ask authors/readers for more resources
The interferon (IFN) response is a critical arm of the innate immune response and a major host defense mechanism against viral infections. Following microbial encounter, a series of signaling events lead to transcriptional activation of the IFN genes, which in turn leads to significant changes in the cellular transcriptome by altering the expression of hundreds of target genes. Emerging evidence suggests that long non-coding RNAs (lncRNAs) constitute a major subgroup of the IFN target genes, and further, that the IFN response is subject to regulation by a large number of host-and pathogen-derived lncRNAs. While the vast majority of IncRNAs with potential roles in the IFN response remain unstudied, analysis of a very small subset provides a glimpse of the regulatory impact of this class of RNAs on IFN response. (C) 2015 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available