Journal
VIRUS RESEARCH
Volume 212, Issue -, Pages 146-160Publisher
ELSEVIER
DOI: 10.1016/j.virusres.2015.07.003
Keywords
Long non-coding RNA; Whole genome RNA-sequencing; Immune system; Epigenetics; Transcriptional regulation
Categories
Funding
- National Institutes of Health [R01 A1044924, R21 AR063846]
- National Science Foundation Graduate Research Fellowship Program [DGE0909667]
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Long noncoding RNAs (IncRNAs) represent a newly discovered class of regulatory molecules that impact a variety of biological processes in cells and organ systems. In humans, it is estimated that there may be more than twice as many IncRNA genes than protein-coding genes. However, only a handful of IncRNAs have been analyzed in detail. In this review, we describe expression and functions of IncRNAs that have been demonstrated to impact innate and adaptive immunity. These emerging paradigms illustrate remarkably diverse mechanisms that IncRNAs utilize to impact the transcriptional programs of immune cells required to fight against pathogens and maintain normal health and homeostasis. (C) 2015 Elsevier B.V. All rights reserved.
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