Journal
VIROLOGY
Volume 493, Issue -, Pages 1-11Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2016.02.014
Keywords
GADD45; HIV-1; LTR; Transcription; Latency
Categories
Funding
- Chinese Ministry of Health [2012ZX10001006]
- National Natural Science Foundation of China [81271812, 81501747, 81571988]
- 111 Project [B08011]
- Tianjin Research Program of Application Foundation and Advanced Technology [15JCQNJC09600]
- State Scholarship Fund from China Scholarship Council (CSC)
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GADD45 proteins are a group of stress-induced proteins and participate in various cellular pathways including cell cycle regulation, cell survival and death, DNA repair and demethylation. It was recently shown that HIV-1 infection induces the expression of GADD45 proteins. However, the effect of GADD45 on HIV-1 replication has not been studied. Here, we report that overexpression of GADD45 proteins reduces HIV-1 production through suppressing transcription from the HIV-1 LTR promoter. This inhibitory effect is specific to HIV-1, since GADD45 proteins neither inhibit the LTR promoters from other retroviruses nor reduce the production of these viruses. Knockdown of endogenous GADD45 modestly activates HIV-1 in the J-Lat A72 latency cell line, which suggests GADD45 proteins might play a role in maintaining HIV-1 latency. (C) 2016 Elsevier Inc. All rights reserved.
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