Journal
VETERINARY PATHOLOGY
Volume 53, Issue 2, Pages 244-249Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0300985815620629
Keywords
aging; pathology; health span; life span; longevity; necropsy; histopathology; rodent; mouse model; animal model; cause of death
Categories
Funding
- NCI NIH HHS [CA34196, P30 CA034196] Funding Source: Medline
- NIA NIH HHS [P30 AG025707, P01AG01751, AG25707, P30 AG013280, P30AG013280, P01 AG001751, P30 AG013319, AG13319] Funding Source: Medline
- NIH HHS [R25OD010450, R25 OD010450, R13 OD010920] Funding Source: Medline
- BLRD VA [I01 BX001023] Funding Source: Medline
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Pathology is a discipline of medicine that adds great benefit to aging studies of rodents by integrating in vivo, biochemical, and molecular data. It is not possible to diagnose systemic illness, comorbidities, and proximate causes of death in aging studies without the morphologic context provided by histopathology. To date, many rodent aging studies do not utilize end points supported by systematic necropsy and histopathology, which leaves studies incomplete, contradictory, and difficult to interpret. As in traditional toxicity studies, if the effect of a drug, dietary treatment, or altered gene expression on aging is to be studied, systematic pathology analysis must be included to determine the causes of age-related illness, moribundity, and death. In this Commentary, the authors discuss the factors that should be considered in the design of aging studies in mice, with the inclusion of robust pathology practices modified after those developed by toxicologic and discovery research pathologists. Investigators in the field of aging must consider the use of histopathology in their rodent aging studies in this era of integrative and preclinical geriatric science (geroscience).
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