Journal
VETERINARY JOURNAL
Volume 211, Issue -, Pages 21-25Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tvjl.2016.02.017
Keywords
Ceftiofur; Tulathromycin; Cephalosporins; E. coli; Pigs
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Funding
- Ministerio de Economia y Competitividad of Spain [AGL2011-28836]
- Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria (INIA)
- European Social Fund
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This study assessed the dynamics of cephalosporin resistant (CR) E. coli populations during the life cycle of pigs treated early in life with ceftiofur or tulathromycin. The study was conducted at eight conventional pig farms; four for each treatment with ceftiofur or tulathromycin. At each farm, 70 7-day-old piglets were divided into two groups: a control group (n = 30) and a treatment group (n = 40). Faecal samples were collected on day 0 and on days 2, 7 and 180 post-treatment. Sows were also sampled on day 0. CR E. coli were selected on MacConkey agar with ceftriaxone. On five farms, 7-day-old piglets excreted CR E. coli before treatment associated with the presence of CR E. colt in sows. The occurrence of CR E. coli positive animals decreased with increasing piglet age. The remaining three farms tested negative for CR E. coli during the study period. Results demonstrated great variability in the frequency of CR E. colt positive animals between farms, independent of treatment. Treatment with ceftiofur resulted in a transitory increase in the counts of CR E. colt after 48 h. However, other risk factors including the presence of CR E. coli in sows and animal age were more important than antimicrobial treatment. Accordingly, intervention strategies targeting sows would likely have a beneficial effect in reducing the occurrence of antimicrobial resistance in primary pig production. (C) 2016 Elsevier Ltd. All rights reserved.
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