Journal
VASCULAR PHARMACOLOGY
Volume 84, Issue -, Pages 8-14Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.vph.2016.05.014
Keywords
Vascular calcification; Review; Signaling pathway; Calcifying cells
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Funding
- NIH [P01 HL30568, R01 HL 81397, R01 HL112839]
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Vascular disease, such as atherosclerosis and diabetic vasculopathy, is frequently complicated by vascular calcification. Previously believed to be an end-stage process of unregulated mineral precipitation, it is now well established to be a multi-faceted disease influenced by the characteristics of its vascular location, the origins of calcifying cells and numerous regulatory pathways. It reflects the fundamental plasticity of the vasculature that is gradually being revealed by progress in vascular and stem cell biology. This review provides a brief overview of where we stand in our understanding of vascular calcification, facing the challenge of translating this knowledge into viable preventive and therapeutic strategies. (C) 2016 Elsevier Inc. All rights reserved.
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