Journal
VACCINE
Volume 34, Issue 47, Pages 5700-5703Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2016.09.050
Keywords
Infant innate immunity; Low vaccine response; IRF7; IFN-alpha; IL12p70; RANTES
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Funding
- National Institutes of Health (NIH) [National Institute on Deafness and Other Communications Disorders (NIDCD)] [R01 08671]
- NIH NIAID [R03 AI11700-01]
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We recently identified a population of 10% of infants who respond with sub-protective antibody levels to most routine primary pediatric vaccinations due to altered innate and adaptive immune responses. We term these infants as low vaccine responders (LVRs). Here we report new data showing that TLR7/8 agonist - R848 stimulation of PBMCs of LVR infants elicit significantly lower IFN-alpha, IL-12p70 and IL-1 beta, while inducing higher levels of CCL5 (RANTES) compared to normal vaccine responder (NVR) infants. (C) 2016 Elsevier Ltd. All rights reserved.
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