Journal
ULTRASTRUCTURAL PATHOLOGY
Volume 40, Issue 4, Pages 189-199Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/01913123.2016.1155684
Keywords
Carcinoma; intracellular lumina; prostate; signet cell cribriform; ultrastructure
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Funding
- St. George's University School of Medicine, Newcastle upon Tyne, UK
- Grenada, WI, IC MedTech, El Cajon, CA
- Unite de Recherches en Physiologie Moleculaire, Laboratoire des Cellules et Tissus, Universite de Namur, Belgium
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The intracellular or intracytoplasmic lumen (IL) is an enigmatic histological structure that occurs in various tumor cells. A reassessment of diverse ILs fine-structure micrographs obtained out of previous studies encompassing the human prostate carcinoma (DU145) cell line and xenotransplanted carcinomas enabled us to propose aspects of ILs development in cancer cells: a combination of altered expressions in intercellular contacts and their cytoskeletal components would favor a disarray of self-apical polarity orientation; those defects, associated with a local, entwined enriched membranous structures growing as microvilli-like formations out of a disrupted endoplasm and trans-Golgi sorting, create ILs in cells' perikarya. These misplaced intracytoplasmic domains can become enlarged through spaces made between the finger-like structures by accruing membranes of coalescent intracytoplasmic vesicles then adding microvilli and glycocalyx to constitute ILs. Cationic mucins added with or without a progressive or total loss of microvilli and content generate signet or ring cell, while ILs enlarge. Variable build-ups of these cells' populations in carcinomas result in architectural mix-up of adjacent cells around these voids, misconstrued as new lumen, and establish a cribriform tumor pattern that often implies a poor cancer prognosis. Alternatively, cytotoxic changes caused by anticancer pro-oxidant treatment favor membrane alterations and exaggerate the ILs in xenotransplants into intracellular crypts that accompany other tumor degenerative changes.
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