Journal
ULTRASOUND IN MEDICINE AND BIOLOGY
Volume 42, Issue 5, Pages 1031-1041Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ultrasmedbio.2015.12.012
Keywords
Liver elasticity; Filter-based harmonic imaging; Shear wave elasticity imaging; In vivo
Funding
- National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health [R01 DK092255, R01 DK106957]
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Quantification of liver elasticity is a major application of shear wave elasticity imaging (SWEI) to non-invasive assessment of liver fibrosis stages. SWEI measurements can be highly affected by ultrasound image quality. Ultrasound harmonic imaging has exhibited a significant improvement in ultrasound image quality as well as for SWEI measurements. This was previously illustrated in cardiac SWEI. The purpose of this study was to evaluate liver shear wave particle displacement detection and shear wave velocity (SWV) measurements with fundamental and filter-based harmonic ultrasound imaging. In a cohort of 17 patients with no history of liver disease, a 2.9-fold increase in maximum shear wave displacement, a 0.11 m/s decrease in the overall interquartile range and median SWVand a 17.6% increase in the success rate of SWV measurements were obtained when filter-based harmonic imaging was used instead of fundamental imaging. (C) 2016 World Federation for Ultrasound in Medicine & Biology.
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