Journal
TWIN RESEARCH AND HUMAN GENETICS
Volume 19, Issue 3, Pages 255-261Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/thg.2016.26
Keywords
twin-twin transfusion syndrome; monochorionic twins; amnioreduction; laser surgery; neurodevelopmental outcome
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Twin-twin transfusion syndrome (TTTS) is a severe complication of monochorionic (MC) twin pregnancies associated with high perinatal mortality and morbidity rates. Management in TTTS is a major challenge for obstetricians and neonatologists. Twins with TTTS are often born prematurely after an extremely distressing and highly hazardous fetal period. Follow-up studies report varying rates of cerebral palsy (CP) and long-term neurodevelopmental impairment (NDI). This review discusses the latest findings on the long-term outcome of TTTS survivors, possible risk factors for long-term impairment, and provides recommendations for future research.
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