Journal
TUMOR BIOLOGY
Volume 37, Issue 12, Pages 15399-15410Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1007/s13277-016-5385-3
Keywords
MicroRNA; MiR-335; Cancers; Biomarker
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Funding
- National High Technology Research and Development Program of China [2014AA020604]
- National Natural Science Foundation of China [81272470]
- National key clinical specialist construction Programs of China [2013[544]]
- Major Program of Natural Science Foundation of Jiangsu Province [BL2014090]
- Natural Science Foundation of Jiangsu Province [BK20151579]
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MicroRNAs (miRNAs), a series of small noncoding RNAs that regulate gene expression at the post-transcriptional/translational level, are pivotal in cell differentiation, biological development, occurrence, and development of diseases, especially in cancers. Early studies have shown that miRNA-335 (miR-335) is widely dysregulated in human cancers and play critical roles in tumorigenesis and tumor progression. In this review, we aim to summarize the regulation of miR-335 expression mechanisms in cancers. We focus on the target genes regulated by miR-335 and its downstream signaling pathways involved in the biological effects of tumor growth, invasion, and metastasis both in vitro and in vivo, and analyze the relationships between miR-335 expression and the clinical characteristics of tumors as well as its effects on prognosis. The collected evidences support the potential use of miR-335 in prognosis and diagnosis as well as the therapeutic prospects of miR-335 in cancers.
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