Journal
TUMOR BIOLOGY
Volume 37, Issue 8, Pages 10011-10019Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1007/s13277-016-5060-8
Keywords
TGF-beta pathway; miRNAs; Breast cancer; Metastasis; Therapy
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Funding
- National Natural Science Foundation of China [81272470]
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Transforming growth factor-beta (TGF-beta) signaling pathway is a key regulator of various cancer biologies, including cancer cell migration, invasion, angiogenesis, proliferation, as well as apoptosis, and it is one of indispensable signaling pathways during cancer metastasis. TGF-beta signaling pathway can regulate and be regulated by a series of molecular and signaling pathways where microRNAs (miRNAs) seem to play important roles. miRNAs are small non-coding RNAs that can regulate expressions of their target genes. Emerging evidence suggest that miRNAs participate in various biological and pathologic processes such as cancer cells apoptosis, proliferation, invasion, migration, and metastasis by influencing multiple signaling pathways. In this article, we focus on the interaction between miRNAs and TGF-beta in breast cancer (BC) metastasis through modulating invasion-metastasis-related factors, including epithelial-to-mesenchymal transition (EMT), cancer stem cells (CSCs), matrix metalloproteinase (MMP), tissue inhibitors of MMPs (TIMPs), cell adhesion molecules (CAMs), and tumor microenvironment (TME). Through a clear understanding of the complicated links between TGF-beta pathway and miRNAs, it may provide a novel and safer therapeutic target to prevent BC metastasis.
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