Journal
TUMOR BIOLOGY
Volume 37, Issue 9, Pages 12141-12151Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1007/s13277-016-5094-y
Keywords
Gastric cancer; Metastasis; MicroRNA-125b; NEU1; STARD13
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Funding
- National Natural Science Foundation of China [81472245]
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MicroRNAs have been documented playing key roles in cancer development and progression. Here, we investigate the role of miR-125b in gastric cancer metastasis. We found that the expression of miR-125b was up-regulated in gastric cancer tissue specimens compared with their corresponding nontumorous tissues, and the up-regulated miR-125b level was significantly associated with TNM stage and lymph node-metastasis. Overexpression of miR-125b promoted gastric cancer cell migration and invasion in vitro and metastasis in vivo. STARD13 and NEU1 were identified as direct target genes of miR-125b by luciferase assays, and they were involved in the cell migration and invasion regulated by miR-125b in gastric cancer. Taken together, miR-125b functions as an oncogene in gastric cancer and represents a new potential therapeutic target for gastric cancer.
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