Journal
TUMOR BIOLOGY
Volume 37, Issue 11, Pages 14403-14413Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1007/s13277-016-5307-4
Keywords
Glioma; lncRNAs; Functional roles; Potential biomarkers and therapeutic targets
Categories
Funding
- National High-tech R&D Program of China (863 Program) [2012AA02A517]
- National Natural Science Foundation of China [81373490, 81573508, 81573463]
- Hunan Provincial Science and Technology Plan of China [2015TP1043]
- Open Foundation of Innovative Platform in University of Hunan Province of China [2015-14]
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With the development of whole genome and transcriptome sequencing technologies, a growing body of long non-coding RNAs (lncRNAs) has been identified and is receiving increasing attention. LncRNAs are non-protein encoding transcripts whose functions are crucial for advancing our comprehensive understanding of biological processes in human health and diseases, specifically glioma. It has been established that lncRNAs are differently expressed in the central nervous system and may play a vital role in glioma. As of June 2016, 20 lncRNAs have been identified that may play a role in glioma pathogenesis. Investigation into the role of lncRNAs in glioma may help to identify potential biomarkers which can improve the diagnosis and treatment of glioma. In this paper, we review current understanding of the function of lncRNAs in glioma initiation and progression.
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