Journal
TUMOR BIOLOGY
Volume 37, Issue 10, Pages 13333-13343Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1007/s13277-016-5220-x
Keywords
GPS2; Liposarcoma; DDLPS; WDLPS
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Liposarcoma(LPS) is the most common type of soft tissue sarcoma accounting for 20 % of all adult sarcomas. However, the molecular pathogenesis of this malignancy is still poorly understood. Here, we showed that GPS2 expression was downregulated in LPS and correlated with the prognosis of this disease. In vitro study showed that knockdown of GPS2 resulted in enhanced proliferation and migration of LPS cell line SW872, without significant influence of cell death. Conclusively, our results suggest that GPS2 may act as a tumor suppressor in LPS and serve as a potential prognosis marker for this disease.
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