Journal
TRENDS IN PHARMACOLOGICAL SCIENCES
Volume 37, Issue 10, Pages 858-871Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tips.2016.07.003
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Funding
- Strategic Research Program for Brain Science from MEXT
- Strategic Research Program for Brain Science from AMED
- MEXT [25251021]
- Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS) from AMED
- Grants-in-Aid for Scientific Research [15K06772, 25251021] Funding Source: KAKEN
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Dopamine signaling in the brain is a complex phenomenon that strongly contributes to emotional behaviors. Medium spiny neurons (MSNs) play a major role in dopamine signaling through dopamine D1 receptors (D1Rs) or dopamine D2 receptors (D2Rs) in the striatum. cAMP/protein kinase A (PKA) regulates phosphorylation signals downstream of D1 Rs, which affects the excitability of MSNs, leading to reward-associated emotional expression and memory formation. A combination of phosphoproteomic approaches and the curated KANPHOS database can be used to elucidate the physiological and pathophysiological functions of dopamine signaling and other monoamines. Emerging evidence from these techniques suggests that the Rap1 pathway plays a crucial role in the excitability of MSNs, leading to the expression of emotional behaviors.
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