Journal
TRENDS IN PHARMACOLOGICAL SCIENCES
Volume 37, Issue 8, Pages 714-727Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tips.2016.05.004
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Funding
- National Natural Science Foundation of China [31110103909, 31330075, 31472107, 31572416, 31372319]
- National Basic Research Program of China [2013CB127305, 2012CB124704]
- Youth Innovation Promotion Association CAS
- Nature Science Foundation of Hunan Province [2015JJ2146]
- Special Fund for Agro-scientific Research in the Public Interest [201403047]
- Innovation Research Team Development Program of MOE of China [IRT0945]
- Chinese Academy of Science STS Project [KFJ-EW-STS-063]
- Key Projects in the National Science & Technology Pillar Program [2013BAD21B04]
- Hunan Key Project [2015NK1002]
- Changsha Lvye Biotechnology Limited Company Academician Expert Workstation
- Guangdong Wangda Group Academician Workstation for Clean Feed Technology Research and Development in Swine
- Guangdong Hinapharm Group Academician Workstation for Biological Feed and Feed Additives and Animal Intestinal Health
- Hunan New Wellful Co. Ltd. Academician Workstation
- Hubei Provincial Key Project for Scientific and Technical Innovation [2014ABA022]
- Chinese Academy of Sciences 'Hundred Talent' award
- Hubei Hundred Talent program
- Natural Science Foundation of Hubei Province [2013CFA097, 2013CFB325, 2012FFB04805, 2011CDA131]
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Obesity develops from an imbalance of energy homeostasis and is associated with chronic low-grade inflammation in white adipose tissues (WAT). Inflammation is involved in the pathophysiology of many obesity-induced disorders including insulin resistance and diabetes. Increasing evidence has shown that dietary leucine supplementation positively affects the parameters associated with obesity and obesity-related metabolic disorders. The beneficial effects include increased loss of body weight, reduced WAT inflammation, improved lipid and glucose metabolism, enhanced mitochondrial function, and preserved lean body mass. Although these beneficial effects have not been clearly established, dietary leucine supplementation, either alone or as part of a therapeutic regimen, may be a good nutritional tool in the prevention and management of obesity and obesity-induced metabolic disorders.
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